Department of chemistry, virginia commonwealth university, 1001 west main st. In press, journal preproof, available online 11 may 2020. Oxidation to a sulfone and removal of the sisopropyl group were not tolerated. If you switch to a different device, you may be asked to login again with only your acs id. Phosphatase ptp isothiocyanate enzyme inactivation. To have your reference list or bibliography automatically made for. Structureactivity relationships using a rational combinatorial approach laura zaccaroa,b, m. Compound 2 was isolated as a colorless oil, and the ir spectrum showed absorption bands at 3500 broad, 1719 and 1650 cm 1.
Received 1 july 2015 revised 19 august 2015 accepted 24 august 2015 available online 24 august 2015 keywords. Received 4 may 2014 revised 1 september 2014 accepted 20 september 2014 available online 28. To ensure successful pdf conversion during online submission, it is important that the author save a new document based on the template, rather than saving the. He has been recognized with a number of awards and honors including the investigator award from the cancer research institute 19931997. Received 12 march 2016 revised 30 march 2016 accepted 31 march 2016 available online 1 april 2016 keywords. The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design, emphasizing new and emerging. The recapitulation of many native like protein properties lends credence.
Rajad, pankaj melkanid, vikas dixitd, umesh patild, ritesh shrivastavab, sandip. Compound 18, which combined the cmethyl group and a c,d trans double. The macrocycle of leinamycin imparts hydrolytic stability to the thiolsensing 1,2dithiolan3one 1oxide unit of the natural product santhosh sivaramakrishnana, leonid breydoa, daekyu sunc, kent s. Articles in press latest issue article collections all issues submit your article. Get article recommendations from acs based on references in your mendeley library. Laboratory of medicinal chemistry, department of chemistry, clemson university, clemson, sc 29634, usa article info article history. They are posted online prior to technical editing, formatting for publication, and author proofing. Together, the results for compounds 79 suggest that while the hydrogenbonding elements of the c3 substituent may be. Youve supercharged your research process with acs and mendeley. Table 1 ic 50 values and some physicochemical properties for adamantylaryl seh inhibitors 1aq. Mass spectra showing molecular ions of 5ohp obtained from the oxidation of propranolol with aap 1 u m1, 0. Articles are in the form of communications reporting experimental or theoretical results of special interest. Cravatt is the norton b gilula professor of chemical biology at the scripps research institute.
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